Successful Use of High Dose Methotrexate in Treatment of Primary CNS Lymphoma Patients Without Access to Serum Methotrexate Levels Monitoring: Challenges and Outcome.

Charanpreet SinghArihant JainAastha TakkarAniruddha AgarwalManish RohillaDeepesh LadAlka KhadwalRajender BasherB D RadotraAmanjit BalAshim DasVishali GuptaVivek LalSubhash VarmaPankaj MalhotraGaurav Prakash

Published in: Indian journal of hematology & blood transfusion : an official journal of Indian Society of Hematology and Blood Transfusion (2021)

All attempts should be made to have therapeutic drug level monitoring for administration of HDMTX based therapy for the patients with PCNSL, more so in patients who have poor performance status and a high IELSG score. If it is imperative to give HDMTx without access to TDM facility then a possible risk of higher toxicity should be explained to all patients, beforehand.

Keyphrases

end stage renal disease
high dose
ejection fraction
newly diagnosed
chronic kidney disease
prognostic factors
peritoneal dialysis
emergency department
low dose
oxidative stress
combination therapy
drug induced