Capillary dysfunction in healthy elderly APOE ε4 carriers with raised brain Aβ deposition.
Lasse Stensvig MadsenPernille Louise KjeldsenRola IsmailPeter ParboLeif ØstergaardDavid James BrooksSimon Fristed EskildsenPublished in: Alzheimer's & dementia : the journal of the Alzheimer's Association (2023)
Alzheimer's disease (AD) is associated with disturbances in microvascular circulation. Capillary dysfunction can be detected in preclinical AD. As cognitive symptoms progress in prodromal AD, capillary dysfunction worsens. Capillary dysfunction may impede the clearance of beta-amyloid (Aβ). Capillary dysfunction might contribute to the development of AD.