Exogenous supply of Hsp47 triggers fibrillar collagen deposition in skin cell cultures in vitro.
Essak S KhanShrikrishnan SankaranLorena LlontopAránzazu Del CampoPublished in: BMC molecular and cell biology (2020)
A 3-fold enhancement of collagen deposition was observed in fibroblasts upon repeated dosage of Hsp47 within the first 6 days of culture. Our results provide fundamental understanding towards the idea of using Hsp47 as therapeutic protein to treat collagen disorders.