KLF7 regulates super-enhancer-driven IGF2BP2 overexpression to promote the progression of head and neck squamous cell carcinoma.

Hongshi CaiJianfeng LiangYaoqi JiangZiyi WangHongyu LiWenjin WangCheng WangJin-Song Hou

Published in: Journal of experimental & clinical cancer research : CR (2024)

Our study reveals the critical role of IGF2BP2 overexpression mediated by SE and KLF7 in promoting HNSCC progression. Targeting SE-associated transcriptional programs may represent a potential therapeutic strategy in managing HNSCC.

Keyphrases

transcription factor
binding protein
cell proliferation
public health
gene expression
growth hormone
cancer therapy
drug delivery
oxidative stress
signaling pathway
heat shock