Shelterin Dysfunction Promotes CD4+ T Cell Senescence in Behçet's Disease.
Jing ShiMenghao ZhangLili ZhangXin YuLuxi SunJinjing LiuYan ZhaoWenjie ZhengPublished in: Rheumatology (Oxford, England) (2023)
Our study demonstrated that TRF2 deficiency in BD naïve CD4+ T cells promoted cell apoptosis and senescence, leading to proinflammatory cytokines overproduction. Therefore, restoring TRF2 might be a promising therapeutic strategy for BD.