AICAR and nicotinamide treatment synergistically augment the proliferation and attenuate senescence-associated changes in mesenchymal stromal cells.

Mohammadhossein Khorraminejad-ShiraziMahsa SaniTahereh Talaei-KhozaniMohammadreza DorvashMalihe MirzaeiMohammad Ali FaghihiAhmad MonabatiArmin Attar

Published in: Stem cell research & therapy (2020)

Selective inhibition of mTORC1 by AICAR and NAM boosts autophagy, retains MSCs' self-renewal and multi-lineage differentiation capacity, and postpones senescence-associated changes after prolonged in vitro culture. Additionally, co-administration of AICAR and NAM shows an additive or probably a synergistic effect on cellular senescence.

Keyphrases

dna damage
endothelial cells
stress induced
signaling pathway
mesenchymal stem cells
cell death
oxidative stress
endoplasmic reticulum stress
single cell
umbilical cord
combination therapy
replacement therapy