Detection of novel mitochondrial mutations in cytochrome C oxidase subunit 1 (COX1) in patients with familial adenomatous polyposis (FAP).
E AfkhamiMohammad Mehdi HeidariM KhatamiF GhadamyariS DianatpourPublished in: Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico (2019)
Our findings indicate a high frequency of mtDNA mutations in all of the FAP cases compared to matched controls. These data significantly enhance our understanding of how such mutations contribute to cancer pathologies and develop the cancer treatment methods by new diagnostic biomarkers, and new drugs for gene therapy.
Keyphrases
- high frequency
- gene therapy
- transcranial magnetic stimulation
- oxidative stress
- papillary thyroid
- mitochondrial dna
- copy number
- big data
- dna methylation
- gene expression
- label free
- young adults
- loop mediated isothermal amplification
- squamous cell
- real time pcr
- genome wide
- deep learning
- data analysis
- chronic rhinosinusitis