Porphyrins as Chelating Agents for Molecular Imaging in Nuclear Medicine.
Krystyna PyrzyńskaKrzysztof KilianMateusz PęgierPublished in: Molecules (Basel, Switzerland) (2022)
Porphyrin ligands, showing a significant affinity for cancer cells, also have the ability to chelate metallic radioisotopes to form potential diagnostic radiopharmaceuticals. They can be applied in single-photon emission computed tomography (SPECT) and positron emission tomography (PET) to evaluate metabolic changes in the human body for tumor diagnostics. The aim of this paper is to present a short overview of the main metallic radionuclides complexed by porphyrin ligands and used in these techniques. These chelation reactions are discussed in terms of the complexation conditions and kinetics and the complex stability.
Keyphrases
- positron emission tomography
- computed tomography
- pet ct
- photodynamic therapy
- endothelial cells
- metal organic framework
- pet imaging
- magnetic resonance imaging
- induced pluripotent stem cells
- energy transfer
- electron transfer
- contrast enhanced
- image quality
- dual energy
- magnetic resonance
- risk assessment
- climate change
- aqueous solution