Screening for precancerous anal lesions with P16/Ki67 immunostaining in HIV-infected MSM.

Sergio Serrano-VillarBeatriz Hernández-NovoaAmparo de BenitoJorge Del RomeroAntonio OcampoJosé Ramón BlancoMar MasiáElena SendagortaGonzalo SanzSantiago MorenoJosé A Pérez-Molina

Published in: PloS one (2017)

In HIV-infected MSM P16/Ki67 immunostaining does not improve the diagnostic accuracy of anal cytology, which shows a high sensitivity yet poor specificity. Other approaches aimed at improving the diagnostic accuracy of current techniques for the diagnostic of precancerous HSIL are warranted.

Keyphrases

hiv infected
high grade
men who have sex with men
antiretroviral therapy
hiv testing
neoadjuvant chemotherapy
human immunodeficiency virus
fine needle aspiration
squamous cell carcinoma
structural basis