Liothyronine could block the programmed death-ligand 1 (PDL1) activity: an e-Pharmacophore modeling and virtual screening study.

Navid PourzardoshtZahra Sadat HashemiMaysam Mard-SoltaniAbolfazl JahangiriMohammad Reza RahbarAlireza ZakeriEbrahim MirzajaniSaeed Khalili

Published in: Journal of receptor and signal transduction research (2020)

The ability of T3 in PD1/PD-L1 checkpoint blockade along with its potential in T4 reduction could be a desirable combination in cancer treatment. These abilities of T3 could be used to restore the ability of the immune system to eliminate tumor cells.

Keyphrases

dna damage
molecular docking
molecular dynamics
cell cycle
oxidative stress
cell proliferation
molecular dynamics simulations