Silence of a dependence receptor CSF1R in colorectal cancer cells activates tumor-associated macrophages.
Mingxuan ZhuLiangliang BaiXiaoxia LiuShaoyong PengYumo XieHong BaiHuichuan YuXiaolin WangPing YuanRui MaJinxin LinLinping WuMeijin HuangYingjie LiYanxin LuoPublished in: Journal for immunotherapy of cancer (2023)
Our findings revealed that CSF1R is a novel identified dependence receptor silenced in CRC. The silence abalienates its ligands to stimulate CSF1R expressed on M2 TAMs, which is an appealing therapeutic target for M2 TAM depletion and CRC treatment.