CSF sphingolipids are correlated with neuroinflammatory cytokines and differentiate neuromyelitis optica spectrum disorder from multiple sclerosis.
Lisa ShiLaura GhezziChiara FenoglioAnna Margherita PietroboniDaniela GalimbertiFrancesca PaceTodd A HardyLaura PiccioAnthony Simon DonPublished in: Journal of neurology, neurosurgery, and psychiatry (2024)
CSF sphingolipids are positively correlated with markers of neuroinflammation and differentiate NMOSD from MS. The inverse correlation between EDSS and CE(16:0) levels may reflect poor clearance of cholesterol released during myelin break-down and warrants further investigation as a biomarker of therapeutic response.