An additive destabilising effect of compound T60I and V122I substitutions in ATTRv amyloidosis.

Tatiana ProkaevaElena S KlimtchukPolina FeschenkoBrian SpencerHaili CuiEric J BurksRoshanak AslebaghKhaja MuneeruddinScott A ShafferElizabeth VargheseJohn L Berk Lawreen H Connors

Published in: Amyloid : the international journal of experimental and clinical investigation : the official journal of the International Society of Amyloidosis (2022)

data indicate that the destabilising effect of individual T60I and V122I variants appears to be additive rather than synergistic.

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