Discovery and validation of a transcriptional signature identifying homologous recombination-deficient breast, endometrial and ovarian cancers.

Guillaume BeinsePierre-Alexandre JustMarie-Aude Le Frere BeldaPierre Laurent-PuigSebastien JacquesMeriem KoualSimon Garinet Karen LeroyNicolas DelanoyHelene BlonsClaire GervaisCatherine DurduxCharles ChapronFrançois GoldwasserBenoit TerrisCecile BadoualValérie TalyAnne-Sophie BatsBruno BorgheseJérôme Alexandre

Published in: British journal of cancer (2022)

UCEC/BRCA/OV with HRD-associated genomic scars share a common transcriptional profile. RNAseq signatures might be relevant for identifying HRD-gynaecological cancers, for prognostication and for therapeutic decision.

Keyphrases

dna repair
dna damage
transcription factor
gene expression
small molecule
heat shock
copy number
high throughput
genome wide
decision making
endometrial cancer
platelet rich plasma
young adults
childhood cancer
breast cancer risk