Effect of upfront intensive therapy on oncological outcomes in older patients with high tumor burden metastatic castration-sensitive prostate cancer: A multicenter retrospective study.

Yuki MiuraShingo HatakeyamaShintaro NaritaTakahiro KimuraKenichi HataShahrokh F ShariatToshikazu TanakaNoritaka IshiSadafumi KawamuraSenji HoshiShigeto IshidoyaKoji MitsuzukaAkihiro ItoNorihiko TsuchiyaShin EgawaTomonori HabuchiChikara Ohyama

Published in: The Prostate (2022)

Patients aged ≥75 years who received upfront intensive therapy had significantly longer CRPC-FS and OS compared with similar age patients treated with conventional therapy in real-world practice. The oncological benefit may not diminish in this older population.

Keyphrases

prostate cancer
radical prostatectomy
physical activity
small cell lung cancer
squamous cell carcinoma
ejection fraction
newly diagnosed
type diabetes
metabolic syndrome
skeletal muscle
chronic kidney disease