CSF hyperdynamics in rats mimicking the obesity and androgen excess characteristic of patients with idiopathic intracranial hypertension.
Jonathan H WardmanSøren Norge AndreassenTrine L Toft-BertelsenMette Nyholm JensenJens E WilhjelmBjarne StyrishaveSteffen HamannSteffen HeegaardAlexandra J SinclairNanna MacAulayPublished in: Fluids and barriers of the CNS (2024)
Obesity in itself therefore does not suffice to recapitulate the IIH symptoms in rats, but modulation of CSF dynamics appears with adjuvant testosterone treatment, which mimics the androgen excess observed in female IIH patients. Obesity-induced androgen dysregulation may thus contribute to the disease mechanism of IIH and could potentially serve as a future therapeutic target.
Keyphrases
- insulin resistance
- metabolic syndrome
- weight loss
- type diabetes
- high fat diet induced
- weight gain
- end stage renal disease
- ejection fraction
- newly diagnosed
- blood pressure
- chronic kidney disease
- early stage
- prognostic factors
- peritoneal dialysis
- replacement therapy
- body mass index
- diabetic rats
- high glucose
- depressive symptoms
- cerebrospinal fluid
- current status
- physical activity
- patient reported outcomes
- oxidative stress
- optic nerve
- optical coherence tomography
- patient reported