Login / Signup

Naïve Bayesian Models for Vero Cell Cytotoxicity.

Alexander L PerrymanJimmy S PatelRiccardo RussoEric SingletonNancy ConnellSean EkinsJoel S Freundlich
Published in: Pharmaceutical research (2018)
The results from external tests demonstrate that our novel cytotoxicity Bayesian model displays sufficient predictive power to help guide translational research. To assist the chemical tool and drug discovery communities, our curated training set is being distributed as part of the Supplementary Material. Graphical Abstract Naive Bayesian models have been trained with publically available data and offer a useful tool for chemical biology and drug discovery to select for small molecules with a high probability of exhibiting acceptably low Vero cell cytotoxicity.
Keyphrases
  • drug discovery
  • single cell
  • cell therapy
  • stem cells
  • machine learning
  • electronic health record
  • high intensity
  • data analysis