Decoding distinctive features of plasma extracellular vesicles in amyotrophic lateral sclerosis.

Laura PasettoStefano CallegaroAlessandro CorbelliFabio FiordalisoDeborah FerraraLaura BrunelliGiovanna SestitoRoberta PastorelliElisa BianchiMarina CretichMarcella ChiariCristina PotrichCristina MogliaMassimo CorboGianni SorarùChristian LunettaAndrea CalvoAdriano ChiòGabriele MoraMaria PennutoAlessandro QuattroneFrancesco RinaldiVito Giuseppe D'AgostinoManuela BassoValentina Bonetto

Published in: Molecular neurodegeneration (2021)

Our analysis unmasked features in plasma EVs of ALS patients with potential straightforward clinical application. We conceived an innovative mathematical model based on machine learning which, by integrating EV size distribution data with protein cargoes, gave very high prediction rates for disease diagnosis and prognosis.

Keyphrases

machine learning
big data
artificial intelligence
electronic health record
risk assessment
small molecule