Metal-free one-pot α-carboxylation of primary alcohols.
Gydo van der HeijdenJasper KraakmanJasper BiemoltEelco RuijterRomano V A OrruPublished in: Organic & biomolecular chemistry (2018)
An efficient metal-free procedure for the formal α-carboxylation of primary alcohols has been developed. The method involves a one-pot oxidation/Passerini/hydrolysis sequence and provides access to α-hydroxy acids bearing a broad range of functional groups. A minor modification to the reaction conditions extends the range of accessible products to α-hydroxy esters.