Highly Bright Near-Infrared Chemiluminescent Probes for Cancer Imaging and Laparotomy.
Xin WeiJingsheng HuangChi ZhangCheng XuKanyi PuYan ZhangPublished in: Angewandte Chemie (International ed. in English) (2023)
Near-infrared (NIR) chemiluminescence imaging holds potential for sensitive imaging of cancer due to its low background; however, few NIR chemiluminophores are available, which share the drawback of low chemiluminescence quantum yields (Φ CL ). Herein, we report the synthesis of NIR chemiluminophores for cancer imaging and laparotomy. Molecular engineering of the electron-withdrawing group at the para-position of the phenol-dioxetane leads to a highly bright NIR chemiluminophore (DPT), showing the Φ CL (4.6×10 -2 Einstein mol -1 ) that is 3 to 5-fold higher than existing NIR chemiluminophores. By caging the phenol group of DPT with a cathepsin B (CatB) responsive moiety, an activatable chemiluminescence probe (DPT CB ) is developed for real-time turn-on detection of deeply buried tumor tissues in living mice. Due to its high brightness, DPT CB permits accurate chemiluminescence-guided laparotomy.
Keyphrases
- fluorescence imaging
- fluorescent probe
- high resolution
- photodynamic therapy
- living cells
- papillary thyroid
- sensitive detection
- drug release
- squamous cell
- energy transfer
- small molecule
- gene expression
- molecularly imprinted
- climate change
- quantum dots
- loop mediated isothermal amplification
- skeletal muscle
- insulin resistance
- cancer therapy
- human health
- wild type