Genomic Insights into Myasthenia Gravis Identify Distinct Immunological Mechanisms in Early and Late Onset Disease.
Lahiru HandunnetthiBogdan KnezevicSilva KaselaKatie L BurnhamLili MilaniSarosh R IraniHai FangJulian C KnightPublished in: Annals of neurology (2021)
The disease-relevant genes identified in this study are a unique resource for many disciplines, including clinicians, scientists, and the pharmaceutical industry. The distinct immunological pathways linked to early and late onset myasthenia gravis carry important implications for drug repurposing opportunities and for future studies of drug development. ANN NEUROL 2021;90:455-463.