Low-Dose Colchicine Ameliorates Doxorubicin Cardiotoxicity Via Promoting Autolysosome Degradation.

Ying PengZhonggen LiJianchao ZhangYunshu DongChenglin ZhangYiming DongYafei ZhaiHonglin ZhengMengduan LiuJing ZhaoWenting DuYangyang Liu Liping SunXiaowei LiHailong Tao De-Yong Long Xiaoyan Zhao Xin Du Chang Sheng Ma Yaohe Wang Jianzeng Dong

Published in: Journal of the American Heart Association (2024)

Our research has shown that a low dose of colchicine is pivotal in restoring the autophagy activity, thereby attenuating the cardiotoxicity induced by doxorubicin. Consequently, colchicine emerges as a promising therapeutic candidate to improve doxorubicin cardiotoxicity.

Keyphrases

low dose
drug delivery
cancer therapy
high dose
cell death
oxidative stress
endoplasmic reticulum stress
mouse model