Detachable adhesives with simultaneously high bonding strength and detaching efficiency have remained a great challenge in adhesion science. The existing detachable adhesives (e.g., solid-liquid phase transitions-based adhesives) usually show low initial cohesion and require long detaching time (several minutes or hours for transitions). Herein, by introducing ionic liquids (ILs) and soft polyethylene glycol (PEG) into a rigid epoxy precursor and curing, we demonstrated the adhesives with both high initial bonding strength (>13 MPa) and detaching efficiency (100% detachment within 10 s under a 90 V DC voltage). The high initial bonding strength is due to the imidazolium cations of ILs and their ion-dipole interactions with PEG can promote the curing of epoxy, decrease the glass-transition temperature, increase the interfacial wettability, and transmit external stress. Also, the outstanding detaching efficiency is because the tetrafluoroborate anions of ILs can electrochemically react rapidly under a voltage and generate fluorinated nanoparticles at the bonding interface within 1 minute. The high bonding and electrochemistry-induced detaching mechanism were further characterized. This work opens up a new avenue for the rational design of fast-detachable adhesives with high bonding strength, showing wide potential in many modern fields.