Increased effort during partial ventilatory support is not associated with lung damage in experimental acute lung injury.
Dietrich HenzlerAlf SchmidtZhaolin XuNada IsmaielHaibo ZhangArthur S SlutskyPaolo PelosiPublished in: Intensive care medicine experimental (2019)
In experimental ALI in rodents, the respiratory effort was increased by reducing the pressure support during partial ventilatory support. In the presence of a constant peak inspiratory transpulmonary pressure, an increased respiratory effort was not associated with worsening ventilator-associated lung injury measured by histologic score and biologic markers.