Neoadjuvant chemoradiation alters biomarkers of anticancer immunotherapy responses in locally advanced rectal cancer.

Incheol SeoHye Won LeeSang Jun ByunJee Young ParkHyeonji MinSung Hwan LeeJu-Seog LeeShin KimSung Uk Bae

Published in: Journal for immunotherapy of cancer (2021)

Taken together, our findings demonstrated that neoadjuvant CRT modulated the immune-related characteristics of LARC, suggesting that neoadjuvant CRT may enhance the responsiveness of LARC to immunotherapy.

Keyphrases

rectal cancer
locally advanced
neoadjuvant chemotherapy
phase ii study
squamous cell carcinoma
cardiac resynchronization therapy
radiation therapy
heart failure
lymph node
study protocol