Sono-synthesis approach improves anticancer activity of ZnO nanoparticles: reactive oxygen species depletion for killing human osteosarcoma cells.
Mansoureh ParsaMohammad Hasan EntezariAzadeh MeshkiniPublished in: Nanomedicine (London, England) (2021)
Aim: To investigate the effect of ultrasound during the synthesis of ZnO nanoparticles (NPs) on their anticancer activity. Materials & methods: ZnO NPs were synthesized in the presence and absence of ultrasonic irradiation. Biological tests were performed on human osteosarcoma cancer cells (Saos-2). Results: The sono-synthesized sample indicated higher cytotoxicity than the conventional one. (IC50 = 16.48 ± 0.41 μg/ml for sonochemical ZnO; 26.96 ± 0.33 μg/ml for conventional ZnO). Both sonochemical and conventional samples acted like antioxidants and reduced intracellular reactive oxygen species level. This reduction was more significant in cells treated with the sono-synthesized sample. The sono-synthesized ZnO NPs showed more tumor selectivity than the conventional sample. Conclusion: Sono-synthesis of ZnO NPs by a bath sonicator could improve their anticancer activity.
Keyphrases
- room temperature
- quantum dots
- reactive oxygen species
- reduced graphene oxide
- oxide nanoparticles
- visible light
- endothelial cells
- induced apoptosis
- light emitting
- cell cycle arrest
- magnetic resonance imaging
- oxidative stress
- induced pluripotent stem cells
- computed tomography
- ionic liquid
- gold nanoparticles
- signaling pathway
- cell proliferation
- ultrasound guided
- walled carbon nanotubes