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Outcomes for patients with head and neck squamous cell carcinoma presenting with N3 nodal disease.

Matthew E WitekAaron M WielandShuai ChenTabassum A KennedyCraig R HullettEvan LiangGregory K HartigRandy J KimplePaul M Harari
Published in: Cancers of the head & neck (2017)
Patients with N3 head and neck squamous cell carcinoma exhibit 5-year overall survival rates of approximately 30% regardless of treatment modality. Planned neck dissection does not improve regional control in patients undergoing definitive chemoradiotherapy. p16-positive patients represent a favorable cohort. Distant failure comprises the major failure pattern and should be the focus of future studies in improving the outcome of this patient cohort.
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