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Pathogenic antibody response to glucose-6-phosphate isomerase targets a modified epitope uniquely exposed on joint cartilage.

Taotao LiChangrong GeAlexander KrämerOuti SareilaMonica Leu AgeliiLinda JohanssonKristina ForslindErik LönnblomMin YangBingze XuQixing LiLei ChengGöran BergströmGonzalo FernandezAlf KastbomSolbritt Rantapää DahlqvistInger GjertssonRickard Holmdahl
Published in: Annals of the rheumatic diseases (2023)
We have identified the major pathogenic B cell epitope of the RA-associated autoantigen GPI, at position 293-307, exposed only on structurally modified GPI on the cartilage surface. B cells to this neo-epitope escape tolerance and could potentially play a role in the pathogenesis of RA.
Keyphrases
  • monoclonal antibody
  • rheumatoid arthritis
  • disease activity
  • ankylosing spondylitis
  • blood glucose
  • blood pressure
  • skeletal muscle
  • systemic sclerosis
  • idiopathic pulmonary fibrosis
  • glycemic control