Cyanine-Functionalized 2,2'-Bipyridine Compounds for Photocatalytic Cancer Therapy.
Zilin ZhuLi WeiAshish Kumar YadavZhongxian FanAshish KumarMengzhao MiaoSamya BanerjeeHuaiyi HuangPublished in: The Journal of organic chemistry (2022)
Recently, interest has been given to developing photocatalytic anticancer drugs. This area of research is dominated by metal complexes. Here, we report the potential of lysosome/mitochondria targeting cyanine appended bipyridine compounds as the organic photocatalytic anticancer agents. The organocatalyst (bpyPCN) not only exhibits light-induced NADH oxidation but also generates intracellular ROS to demonstrate anticancer activity. This is the first example of organic compound induced catalytic NADH photo-oxidation in an aqueous solution and in cancer cells.
Keyphrases
- visible light
- cancer therapy
- aqueous solution
- reactive oxygen species
- reduced graphene oxide
- drug delivery
- cell death
- highly efficient
- high glucose
- water soluble
- drug induced
- diabetic rats
- quantum dots
- dna damage
- fluorescent probe
- electron transfer
- living cells
- high resolution
- risk assessment
- human health
- endoplasmic reticulum
- single molecule