Altered cognitive function in systemic lupus erythematosus and associations with inflammation and functional and structural brain changes.

Michelle BarracloughShane McKieBen ParkerAlan JacksonPhilip PembertonRebecca ElliottIan N Bruce

Published in: Annals of the rheumatic diseases (2019)

Sustained attention was impaired in patients with SLE. Poor attenuation of the DMN may contribute to cognitive impairments in SLE and our data suggest that in addition to mood and fatigue inflammatory mechanisms and organ damage impact cognitive functioning in SLE. The multifaceted nature of CD in SLE means any therapeutic interventions should be individually tailored.

Keyphrases

systemic lupus erythematosus
disease activity
oxidative stress
rheumatoid arthritis
sleep quality
physical activity
working memory
bipolar disorder
electronic health record
white matter
resting state
multiple sclerosis
machine learning
smoking cessation
functional connectivity