Deaminative defluoroalkylation of α-trifluoromethylalkenes enabled by photoredox catalysis.
Guodong ZhangLei WangLiping CuiPan GaoFeng ChenPublished in: Organic & biomolecular chemistry (2023)
Herein, we disclose a new photoredox-catalysed strategy to access gem -difluoroallylarenes from α-trifluoromethylalkenes with sterically hindered primary amines via C-N and C-F bond activation. This deaminative and defluorinative allylation is generally compatible with diverse functional groups and sterically hindered α-3° and 2° primary amines.
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