Login / Signup

Diazepam-based covalent modifiers of GPX4 induce ferroptosis in liver cancer cells.

Dharmendra K YadavSona TiwariSathyapriya SenthilSai Kumari VechalapuSanthosh DuraisamyViral RawatMohammed Isfahur RahmanShweta KhannaDharmaraja Allimuthu
Published in: Chemical communications (Cambridge, England) (2024)
Developing new chemotherapeutics that are structurally and mechanistically unique is needed due to the rapid rise of the cancer incidence across the globe. Here, we report the identification of irreversible, thiol-reactive diazepam derivatives as GPX4 modifiers and nanomolar inducers of ferroptosis in liver cancer cells.
Keyphrases
  • cell death
  • papillary thyroid
  • risk factors
  • squamous cell
  • childhood cancer
  • lymph node metastasis