Callosal Function in Pediatric Traumatic Brain Injury Linked to Disrupted White Matter Integrity.
Emily L DennisMonica U EllisSarah D MarionYan JinLisa MoranAlexander OlsenClaudia KernanTalin BabikianRichard B MinkChristopher BabbittJeffrey JohnsonChristopher C GizaPaul M ThompsonRobert F AsarnowPublished in: The Journal of neuroscience : the official journal of the Society for Neuroscience (2015)
Traumatic brain injury (TBI) is the primary cause of death and disability in children and adolescents. There is considerable heterogeneity in postinjury outcome, which is only partially explained by injury severity. Imaging biomarkers may help explain some of this variance, as diffusion weighted imaging is sensitive to the white matter disruption that is common after injury. The corpus callosum (CC) is one of the most commonly reported areas of disruption. In this multimodal study, we discovered a divergence within our pediatric moderate-to-severe TBI sample 1-5 months postinjury. A subset of the TBI sample showed significant impairment in CC function, which is supported by additional results showing deficits in CC structural integrity. This subset also had poorer neurocognitive functioning. Our research sheds light on postinjury heterogeneity.
Keyphrases
- traumatic brain injury
- white matter
- diffusion weighted imaging
- multiple sclerosis
- single cell
- severe traumatic brain injury
- high resolution
- magnetic resonance imaging
- early onset
- pain management
- contrast enhanced
- magnetic resonance
- mass spectrometry
- resting state
- computed tomography
- photodynamic therapy
- fluorescence imaging