Diagnostic accuracy of genetic markers and nucleic acid techniques for the detection of Leptospira in clinical samples: A meta-analysis.

Jia-Yong LamGary Kim-Kuan Low Hui-Yee Chee

Published in: PLoS neglected tropical diseases (2020)

The diagnostic accuracies of the studies examined for each genetic marker showed a significant heterogeneity. The secY gene exhibited higher diagnostic accuracy measures compared with other genetic markers, such as lipL32, flaB, and rrs, but the difference was not significant. Thus, these genetic markers had no significant difference in diagnostic accuracy for leptospirosis. Further research into these genetic markers is warranted.

Keyphrases

genome wide
copy number
nucleic acid
dna methylation
gene expression
transcription factor
sensitive detection