A phase I study of sirolimus in combination with metronomic therapy (CHOAnome) in children with recurrent or refractory solid and brain tumors.

Muna QayedThomas CashMourad TighiouartTobey J MacDonaldKelly C GoldsmithRachel TanosLeslie KeanBenjamin WatkinsYvonne SuessmuthCynthia WetmoreHoward M Katzenstein

Published in: Pediatric blood & cancer (2019)

The combination of sirolimus with metronomic chemotherapy is well tolerated in children. A phase II trial of this combination is ongoing.

Keyphrases

young adults
clinical trial
stem cells
open label
radiation therapy
mesenchymal stem cells
bone marrow
study protocol
cell therapy