Role and regulation of proapoptotic Bax in oral squamous cell carcinoma and drug resistance.

Manzar AlamTanushree KashyapPrajna MishraAditya K PandaSiddavaram NaginiRajakishore Mishra

Published in: Head & neck (2018)

Hence, the Bax gene alteration and its deregulation through p53/Akt pathway are important for OSCC progression and drug resistance. Akt Inhibitor VIII and nimbolide synergistically induce Bax, and it is therefore beneficial for chemosensitizing cisplatin-resistant human OSCC.

Keyphrases

induced apoptosis
signaling pathway
cell proliferation
endothelial cells
endoplasmic reticulum stress
induced pluripotent stem cells
copy number
oxidative stress
transcription factor