Optimal alpha-1 antitrypsin level cutoffs for genotype identification in patients with chronic liver disease.

Published in: Hepatology communications (2023)

Significant overlap in A1AT level noted with Pi*MM, MZ, and MS variants. Miss rate of Pi*MZ at a cutoff level <100 was 29%, <110 was 18%, <120 was 8%, and <130 was 4%. We suggest simultaneous measurement of A1AT level and genotype in patients with chronic liver disease.

Keyphrases

mass spectrometry
ms ms