Novel role of microphthalmia-associated transcription factor in modulating the differentiation and immunosuppressive functions of myeloid-derived suppressor cells.

Aram LeeHaesun ParkSoyoung LimJihyun LimJaemoon KohYoon Kyung JeonYoung YangMyeong-Sok LeeJong-Seok Lim

Published in: Journal for immunotherapy of cancer (2023)

Our results indicate that MITF regulates the differentiation and function of MDSCs and can be a novel therapeutic target for modulating MDSC activity in immunosuppressive s.

Keyphrases

transcription factor
induced apoptosis
signaling pathway
cell cycle arrest
dna binding
oxidative stress
cell proliferation
genome wide identification