Anesthesia triggers drug delivery to experimental glioma in mice by hijacking caveolar transport.

Lena SpiethStefan A BerghoffSina K StumpfJan WinchenbachThomas MichaelisTakashi WatanabeNina GerndtTim DükingSabine HoferTorben RuhwedelAli H ShaibKatrin WilligKatharina KronenbergUwe KarstJens FrahmJeong Seop RheeSusana MinguetWiebke MöbiusNiels KruseChristian von der BreliePeter MichelsChristine StadelmannPetra HülperGesine Saher

Published in: Neuro-oncology advances (2021)

Combination therapy, involving isoflurane-mediated BBB permeation with drug administration has far-reaching therapeutic implications for CNS malignancies.

Keyphrases

combination therapy
drug administration
drug delivery
blood brain barrier
high fat diet induced
cancer therapy
metabolic syndrome
insulin resistance
adipose tissue