Effect of antiviral treatment on hepatitis B virus integration and hepatocyte clonal expansion.
Ning ChowDanny Ka-Ho WongChing-Lung LaiLung-Yi MakJames FungHoi-Tang MaMeng-Wai LeiWai-Kay SetoMan-Fung YuenPublished in: Clinical infectious diseases : an official publication of the Infectious Diseases Society of America (2022)
NUCs reduced both HBV DNA integration and hepatocyte clonal expansion, suggesting another alternative pathway besides direct viral suppression to reduce HCC risk. Our findings supported the notion for a long-term NUC treatment to prevent HCC.