Assessing Kidney Graft Viability and Its Cells Metabolism during Machine Perfusion.
Maria Irene BelliniFrancesco TortoriciMaria Ida AmabileVito D'AndreaPublished in: International journal of molecular sciences (2021)
Kidney transplantation is the golden treatment for end-stage renal disease. Static cold storage is currently considered the standard method of preservation, but dynamic techniques, such as machine perfusion (MP), have been shown to improve graft function, especially in kidneys donated by extended criteria donors and donation after circulatory death. With poor organ quality being a major reason for kidneys not being transplanted, an accurate, objective and reliable quality assessment during preservation could add value and support to clinicians' decisions. MPs are emerging technologies with the potential to assess kidney graft viability and quality, both in the hypothermic and normothermic scenarios. The aim of this review is to summarize current tools for graft viability assessment using MP prior to implantation in relation to the ischemic damage.
Keyphrases
- kidney transplantation
- end stage renal disease
- chronic kidney disease
- peritoneal dialysis
- induced apoptosis
- deep learning
- oxidative stress
- climate change
- palliative care
- magnetic resonance imaging
- ischemia reperfusion injury
- contrast enhanced
- cell cycle arrest
- computed tomography
- risk assessment
- cell death
- endoplasmic reticulum stress
- human health