Progesterone promotes immunomodulation and tumor development in the murine mammary gland.
Lauryn R WernerKatelin A GibsonMerit L GoodmanDominika E HelmKatherine R WalterSean M HolloranGloria M TrincaRichard C HastingsHoward H YangYing HuJunping WeiGangjun LeiXiao-Yi YangRashna MadanNapoleone FerraraMary A MarkiewiczPrabhakar ChaliseMargaret L AxelrodJustin M BalkoKent W HunterZachary Conrad HartmanCarol A LangeChristy R HaganPublished in: Journal for immunotherapy of cancer (2022)
Together, these findings offer a novel mechanism of P4-driven mammary gland tumor development and provide rationale in investigating the usage of antiprogestin therapies to promote immune-mediated elimination of mammary gland tumors.
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