Neuroinflammation in Low-Level PM2.5-Exposed Rats Illustrated by PET via an Improved Automated Produced [ 18 F]FEPPA: A Feasibility Study.
Mei-Fang ChengTsun-Jen ChengYue Leon GuoChing-Hung ChiuHung-Ming WuRuoh-Fang YenYa-Yao HuangWen-Sheng HuangChyng-Yann ShiuePublished in: Molecular imaging (2022)
F]FEPPA has been produced in high quantity, high quality, and high reproducibility and, for the first time, used for PET imaging the effects of PM2.5 in the rat brain. It is ready to be used for imaging inflammation in various clinical or preclinical studies, especially for nearby PET centers without cyclotrons.
Keyphrases
- pet imaging
- positron emission tomography
- particulate matter
- air pollution
- computed tomography
- pet ct
- heavy metals
- polycyclic aromatic hydrocarbons
- high resolution
- oxidative stress
- machine learning
- traumatic brain injury
- deep learning
- lipopolysaccharide induced
- water soluble
- cell therapy
- lps induced
- cognitive impairment
- photodynamic therapy
- bone marrow
- cerebral ischemia
- blood brain barrier
- case control