Presence of cells in the polyaneuploid cancer cell (PACC) state predicts the risk of recurrence in prostate cancer.

Levent TrabzonluKenneth J PientaBruce J TrockAngelo M DeMarzo Sarah R Amend

Published in: The Prostate (2022)

Our findings show that the number of PACCs and the number of cores positive for PACCs are statistically significant prognostic factors for metastasis-free survival, after adjusting for CAPRA-S, in a case-cohort of intermediate- or high-risk men who underwent radical prostatectomy. In addition, despite the small number of men with complete data to evaluate time to metastatic castration-resistant PCa (mCRPC), the total number of PACCs was a statistically significant predictor of mCRPC in univariate analysis and suggested a prognostic effect even after adjusting for CAPRA-S.

Keyphrases

radical prostatectomy
prostate cancer
prognostic factors
induced apoptosis
middle aged
electronic health record
big data
machine learning