Age-Related Alterations of Hyaluronan and Collagen in Extracellular Matrix of the Muscle Spindles.

Chenglei Fan Carmelo Pirri Caterina Fede Diego Guidolin Carlo BizLucia PetrelliAndrea PorzionatoVeronica Macchi Raffaele De Caro Carla Stecco

Published in: Journal of clinical medicine (2021)

Age-related collagen accumulation and lower HA in the ECM in which the MSs were embedded may probably cause more stiffness in the ECM in vivo, which could help to partly explain the peripheral mechanisms underlying the age-related decline in functional changes related to MSs.

Keyphrases

extracellular matrix
wound healing
tissue engineering
skeletal muscle
chemotherapy induced