Bromodomain AAA+ ATPases get into shape.

Published in: Nucleus (Austin, Tex.) (2020)

Bromodomain AAA+ ATPases (ATPases associated with diverse cellular activities) are emerging as oncogenic proteins and compelling targets for anticancer therapies. However, structural and biochemical insight into these machines is missing. A recent study by Cho et al. reports the first cryo-EM structure of a bromodomain AAA+ ATPase and provides first insights into the functions of this putative histone chaperone.

Keyphrases

dna methylation
transcription factor
gene expression
heat shock protein