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A latent class approach to identify multi-risk profiles associated with phylogenetic clustering of recent hepatitis C virus infection in Australia and New Zealand from 2004 to 2015.

Sofia R BartlettTanya L ApplegateBrendan P JackaMarianne MartinelloFrancois Mj LamouryMark DantaDaniel BradshawDavid ShawAndrew R LloydMargaret HellardGregory J DoreGail V MatthewsJason Grebely
Published in: Journal of the International AIDS Society (2020)
Clusters containing individuals with specific characteristics suggest that HCV transmission occurs through discrete networks, particularly among HIV/HCV co-infected individuals. The greater proportion of clustering found among HIV/HCV co-infected participants highlights the need to provide broad direct-acting antiviral access encouraging rapid uptake in this population and ongoing monitoring of the phylogeny.
Keyphrases
  • hepatitis c virus
  • human immunodeficiency virus
  • hepatitis c virus infection
  • antiretroviral therapy
  • hiv positive
  • hiv infected
  • hiv testing
  • single cell
  • rna seq
  • hiv aids
  • genetic diversity