Characterizing Molecular and Synaptic Signatures in mouse models of Late-Onset Alzheimer's Disease Independent of Amyloid and Tau Pathology.

Kevin P KotredesRavi S PandeyScott PersohnKierra ElderidgeCharles P BurtonEthan W MinerKathryn A HaynesDiogo Francisco S SantosSean-Paul WilliamsNicholas HeatonCynthia M IngrahamChristopher LloydDylan GarceauRita O'RourkeSarah HerrickClaudia Rangel-BarajasSurendra MaharjanNian WangMichael SasnerBruce T LambPaul R TerritoStacey J Sukoff RizzoGregory W Carter Gareth R Howell Adrian L Oblak

Published in: bioRxiv : the preprint server for biology (2023)

Collectively the comprehensive characterization of LOAD2+HFD mice reveal this model as important for preclinical studies that target features of LOAD independent of amyloid and tau.

Keyphrases

late onset
early onset
cerebrospinal fluid
genome wide
mouse model
high fat diet
cognitive decline
high fat diet induced
single cell
cell therapy
case control
dna methylation
gene expression
adipose tissue
mesenchymal stem cells
single molecule
insulin resistance
bone marrow