Synthesis, Characterization and Photodynamic Activity against Bladder Cancer Cells of Novel Triazole-Porphyrin Derivatives.

Ana T P C GomesRosa FernandesCarlos Fontes RibeiroJoão P C ToméMaria da Graça P M S Neves Fernando de Carvalho da Silva Vítor Francisco Ferreira José A S Cavaleiro

Published in: Molecules (Basel, Switzerland) (2020)

Novel triazole-porphyrin derivatives (TZ-PORs) were synthesized through the Heck reaction and then incorporated into polyvinylpyrrolidone (PVP) micelles. After verifying that this incorporation did not compromise the photophysical and chemical features of TZ-PORs as photosensitizers, the phototoxicity of the formulations towards cancer cells was screened. Biological studies show high photodynamic activity of all PVP-TZ-POR formulations against a bladder cancer cell line with a particular highlight to PVP-TZ-POR 7e and 7f that are able to significantly reduce HT-1376 cell viability, while they had no effect on control ARPE-19 cells.

Keyphrases

induced apoptosis
photodynamic therapy
cell cycle arrest
cancer therapy
drug delivery
endoplasmic reticulum stress
cell death
electron transfer
cell proliferation
metal organic framework
hyaluronic acid
drug release
muscle invasive bladder cancer