Single-cell transcriptome reveals Staphylococcus aureus modulating fibroblast differentiation in the bone-implant interface.

Jinlong YuBoyong WangFeiyang ZhangZun RenFeng JiangMusha HamushanMingzhang LiGeyong GuoHao Shen

Published in: Molecular medicine (Cambridge, Mass.) (2023)

fibroblast in the bone-implant interface. Moreover, we revealed a bipolar mode of fibroblast differentiation and put forward the hypothesis that infection could modulate fibroblast toward a pro-inflammatory phenotype through NPAS2 and TFEC.

Keyphrases

single cell
soft tissue
staphylococcus aureus
rna seq
bone mineral density
wound healing
high throughput
signaling pathway
bone loss
bone regeneration
pseudomonas aeruginosa
methicillin resistant staphylococcus aureus
candida albicans